PDF] Physiological and molecular basis of extreme radioresistance

The most recent advances in understanding on different aspects of D. radiodurans that are shown to be important for its extraordinary radioresistance are reviewed. Deinococcus radiodurans is characterized for its extraordinary radioresistance. An efficient DNA strandbreak repair and strong oxidative stress tolerance are amongst the mechanisms that contribute to its extreme phenotypes. The multipartite genome structure, recombination repair without RecBC enzymes, absence of SOS response and the roles of serine/ threonine protein kinase in DNA damage response, and the small molecules protecting proteins from oxidative damage are some of the other unique features of this bacterium. Here, we review the most recent advances in our understanding on different aspects of D. radiodurans that are shown to be important for its extraordinary radioresistance.

Cancer Manipulation of Host Physiology: Lessons from Pancreatic Cancer: Trends in Molecular Medicine

Extracellular matrix stiffness mediates radiosensitivity in a 3D nasopharyngeal carcinoma model, Cancer Cell International

The radioresistant and survival mechanisms of Deinococcus radiodurans

PDF) Guanine quadruplex DNA regulates gamma radiation response of genome functions in radioresistant bacterium Deinococcus radiodurans

Frontiers Hypoxia-Modified Cancer Cell Metabolism

IJMS, Free Full-Text

Cancer Stem Cell (CSC) Inhibitors in Oncology—A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives

Manganese binding to antioxidant peptides involved in extreme radiation resistance in Deinococcus radiodurans - ScienceDirect

A new perspective on radiation resistance based on Deinococcus radiodurans

The scientific revolution that unraveled the astonishing DNA repair capacity of the Deinococcaceae: 40 years on