Rac1 Regulates Neuronal Polarization through the WAVE Complex
Por um escritor misterioso
Last updated 21 setembro 2024
Neuronal migration and axon growth, key events during neuronal development, require distinct changes in the cytoskeleton. Although many molecular regulators of polarity have been identified and characterized, relatively little is known about their physiological role in this process. To study the physiological function of Rac1 in neuronal development, we have generated a conditional knock-out mouse, in which Rac1 is ablated in the whole brain. Rac1 -deficient cerebellar granule neurons, which do not express other Rac isoforms, showed impaired neuronal migration and axon formation both in vivo and in vitro . In addition, Rac1 ablation disrupts lamellipodia formation in growth cones. The analysis of Rac1 effectors revealed the absence of the Wiskott–Aldrich syndrome protein (WASP) family verprolin-homologous protein (WAVE) complex from the plasma membrane of knock-out growth cones. Loss of WAVE function inhibited axon growth, whereas overexpression of a membrane-tethered WAVE mutant partially rescued axon growth in Rac1 -knock-out neurons. In addition, pharmacological inhibition of the WAVE complex effector Arp2/3 also reduced axon growth. We propose that Rac1 recruits the WAVE complex to the plasma membrane to enable actin remodeling necessary for axon growth.
Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila
Journal of Cellular Physiology, Cell Biology Journal
Cells, Free Full-Text
PDF) Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems
The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton
Frontiers Neuronal Polarity: Positive and Negative Feedback Signals
Neuronal actin cytoskeleton gain of function in the human brain - eBioMedicine
Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems, Neural Development
Development of neuronal polarity in vivo - ScienceDirect
Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice
Rac1 Regulates Neuronal Polarization through the WAVE Complex
Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar–Bipolar Transition
Cancers, Free Full-Text
Neuronal Polarity: Positive and Negative Feedback Signals. - Abstract - Europe PMC
Frontiers Neuronal Polarity: Positive and Negative Feedback Signals
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