Molecules, Free Full-Text
Por um escritor misterioso
Last updated 20 setembro 2024
COVID-19 is an acute respiratory disease caused by SARS-CoV-2 that has spawned a worldwide pandemic. ADAM17 is a sheddase associated with the modulation of the receptor ACE2 of SARS-CoV-2. Studies have revealed that malignant phenotypes of several cancer types are closely relevant to highly expressed ADAM17. However, ADAM17 regulation in SARS-CoV-2 invasion and its role on small molecules are unclear. Here, we evaluated the ADAM17 inhibitory effects of cordycepin (CD), thymoquinone (TQ), and N6, N6-dimethyladenosine (m62A), on cancer cells and predicted the anti-COVID-19 potential of the three compounds and their underlying signaling pathways by network pharmacology. It was found that CD, TQ, and m62A repressed the ADAM17 expression upon different cancer cells remarkably. Moreover, CD inhibited GFP-positive syncytia formation significantly, suggesting its potential against SARS-CoV-2. Pharmacological analysis by constructing CD-, TQ-, and m62A-based drug-target COVID-19 networks further indicated that ADAM17 is a potential target for anti-COVID-19 therapy with these compounds, and the mechanism might be relevant to viral infection and transmembrane receptors-mediated signal transduction. These findings imply that ADAM17 is of potentially medical significance for cancer patients infected with SARS-CoV-2, which provides potential new targets and insights for developing innovative drugs against COVID-19.
Molecules of murder : criminal molecules and classic cases
Molecules Set of 4 Art PRINTABLES Caffeine Happiness Sleep
Molecules, Free Full-Text
Molecules, Free Full-Text
System Mechanic Activator Betamaster - Colaboratory
Molecules, Free Full-Text
Celltype Property Is Null - Colaboratory
Premium Photo Abstract science background with molecules full
Extracellular vesicles remodel tumor environment for cancer
Recomendado para você
-
Contato20 setembro 2024
-
October 2022 - Conejo Valley Village20 setembro 2024
-
Portal do Governo dos Açores - Portal20 setembro 2024
-
Curso Saúde Vocal do Professor - CSVP20 setembro 2024
-
IPTI, Instituto de Pesquisas em Tecnologia e Inovação20 setembro 2024
-
Mystifly closes Pre Series B Funding20 setembro 2024
-
ERDDAP - HYCOM Region 17 3D - Make A Graph20 setembro 2024
-
KB05122022 - CVP/CSVP installation where Powershell policy execution is ALLSIGNED or REMOTESIGNED : Support portal20 setembro 2024
-
Campus Safety & Violence Prevention / Strategic Initiatives / Massachusetts Department of Higher Education20 setembro 2024
-
Midlatitude storms in a moister world: lessons from idealized baroclinic life cycle experiments20 setembro 2024
você pode gostar
-
Pokémon MMO 3D - Videogame published by Pokemon MMO 3D20 setembro 2024
-
heroesonlineroblox #heroesroblox #zukoavatar #heroesonline #roblox #h20 setembro 2024
-
Livro de Xadrez 202 Xeques-Mates Surpreendentes [Sob encomenda: Envio em 45 dias] - A lojinha de xadrez que virou mania nacional!20 setembro 2024
-
CONSOLE XBOX 360 SUPER SLIM 4GB DEST. - CDF Computadores20 setembro 2024
-
Blue Lock Characters Graphic Mens Hawaiian Shirt,Blue Lock Casual20 setembro 2024
-
Sporting Braga e SL Benfica ao vivo onde assistir 17 dezembr, Prime Paddling Group20 setembro 2024
-
Idle Games - Armor Games20 setembro 2024
-
Game Jolt - Share your creations20 setembro 2024
-
Odeio mesmo, #light #lightyagami #kira #deathnote #L #anime #manga #f20 setembro 2024
-
Am I seeing this correctly? M26 on 9anime? it's cam tho. : r/OneTruthPrevails20 setembro 2024