Genes that Escape Silencing on the Second X Chromosome May Drive Disease

When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.

Somatic XIST activation and features of X chromosome inactivation in male human cancers - ScienceDirect

The Xist repeat E deletion alters escape gene expression but not affect

The human inactive X chromosome modulates expression of the active X chromosome - ScienceDirect

Epigenomes, Free Full-Text

Gene regulation in time and space during X-chromosome inactivation

Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

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Escape Artists of the X Chromosome: Trends in Genetics

The study of X-linked tumor suppressor genes challenges the two-hit