A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered

Researchers from the group Mitochondrial regulation of cell death and steatohepatitis have revealed a new role for acid ceramidase (ACDase) in experimental models and in patients with NPC through the regulation of STARD1 and its impact on mitochondrial function.

Niemann-Pick Disease, Types C1 (D)

Lysosomal positioning diseases: beyond substrate storage

Mitochondrial cholesterol trafficking and StARD1 expression in human

From genes to hope

Role of STARD4 and NPC1 in intracellular sterol transport

Adaptations of Energy Metabolism Associated with Increased Levels of Mitochondrial Cholesterol in Niemann-Pick Type C1-deficient Cells* - Journal of Biological Chemistry

A High-Content RNAi-Screening Assay to Identify Modulators of Cholesterol Accumulation in Niemann–Pick Type C Cells

Mitochondrial Cholesterol in Alzheimer's Disease and Niemann–Pick Type C Disease

Early steps in steroidogenesis: intracellular cholesterol trafficking. - Abstract - Europe PMC

IJMS, Free Full-Text

Cells, Free Full-Text

Frontiers Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease

Crohn's Disease in Niemann–Pick Disease Type C1: Caught in the Cross-Fire of Host-Microbial Interactions